A simple, accurate, validated and reproducible UV-spectrophotometric method has been developed for the simultaneous estimation of Ofloxacin (OFL) and Tinidazole (TNZ) in both bulk and tablet formulation. Ofloxacin and Tinidazole in combined tablet formulation were estimated by using the multicomponent mode at 293 nm for Ofloxacin and 278 nm for Tinidazole in their solution in 0.1N HCl solution. The Beer’s law was obeyed in the concentration range of 02-20µg/ml for Ofloxacin and 10-80µg/ml for Tinidazole. Mean recovery of 99.37% and 99.42% for Ofloxacin and Tinidazole respectively signifies the accuracy of the method. Commercial tablets containing 200mg and 600mg of Ofloxacin and Tinidazole (Oflin-TZ and Ofla-TZ) were analyzed by the proposed method and the results were well within the claimed limits. The present work describes a simple, accurate, reproducible, rapid and economic methods for simultaneous estimation of OFL and TNZ in tablet formulation which can be used for the routine simultaneous estimation of these drugs in industries and other analytical laboratories.
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